GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs60843830 | 1 | rs60843830 | chr2:286756 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11 | 1.18E-24 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9309473 | 1 | rs60844734 | chr2:73623205 | ALMS1P | chr2:73872046-73912692:+ | 0.33 | 4.87 | 1.65E-6 | Metabolite levels |
| BLCA | cis | rs6087771 | 1 | rs6087771 | chr20:30306724 | COX4I2 | chr20:30225691-30232800:+ | 0.22 | 4.66 | 4.29E-6 | Subcortical brain region volumes |
| BLCA | cis | rs6087771 | 1 | rs6087779 | chr20:30370566 | COX4I2 | chr20:30225691-30232800:+ | 0.2 | 4.23 | 2.97E-5 | Subcortical brain region volumes |
| BLCA | cis | rs6087771 | 1 | rs6087782 | chr20:30391580 | COX4I2 | chr20:30225691-30232800:+ | 0.21 | 4.34 | 1.82E-5 | Subcortical brain region volumes |
| BLCA | cis | rs12908161 | 1 | rs60957376 | chr15:85280792 | LOC388152 | chr15:84867600-84898920:- | -0.24 | -4.17 | 3.84E-5 | Schizophrenia |
| BLCA | cis | rs9473555 | 1 | rs60982898 | chr6:49385806 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.66 | 2.91E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs60982898 | chr6:49385806 | MUT | chr6:49398994-49431031:- | 0.28 | 5.53 | 5.94E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs4237643 | 1 | rs61037750 | chr11:43681372 | HSD17B12 | chr11:43702143-43878160:+ | -0.44 | -7.23 | 2.69E-12 | Forced vital capacity |
| BLCA | cis | rs61041336 | 1 | rs61041336 | chr16:58733162 | GOT2 | chr16:58741035-58768246:- | 0.3 | 3.94 | 9.67E-5 | Neuritic plaque |
| BLCA | cis | rs2275426 | 1 | rs61102033 | chr1:46382441 | CCDC163P | chr1:45960581-45965646:- | -0.35 | -6.56 | 1.75E-10 | Body mass index |
| BLCA | cis | rs6087771 | 1 | rs6119650 | chr20:30258480 | COX4I2 | chr20:30225691-30232800:+ | 0.22 | 4.56 | 6.89E-6 | Subcortical brain region volumes |
| BLCA | cis | rs6087771 | 1 | rs6119652 | chr20:30259445 | COX4I2 | chr20:30225691-30232800:+ | 0.22 | 4.58 | 6.2E-6 | Subcortical brain region volumes |
| BLCA | cis | rs6120974 | 1 | rs6120974 | chr20:34126827 | CPNE1 | chr20:34213968-34262539:- | -0.55 | -6.66 | 9.49E-11 | Triglycerides |
| BLCA | cis | rs6087771 | 1 | rs6121038 | chr20:30254773 | COX4I2 | chr20:30225691-30232800:+ | 0.22 | 4.71 | 3.48E-6 | Subcortical brain region volumes |